EFFECTS ON NATURAL KILLER (NK) AND LYMPHOKINE ACTIVATED KILLER (LAK) ACTIVITY OF PERIPHERAL MONONUCLEAR CELLS TREATED WITH ASTHMA DRUGS

概要

論文の詳細を見る
NK activity and LAK activity were estimated in normal mononuclear cells treated with Aminophylline (AMIN), Procaterol hydrochloride (PROC) or Azelastin hydrochloride (AZPT).1. NK activities were suppressed in a dose-dependent manner by treatment with AMIN or PROC. However, the suppression was only slight at pharmacological doses, and the decreased NK activities were restored to normal ranges by Interferon-α (IFN-α) administration.No Suppression was observed with AZPT treatment.2. LAK activity was suppressed in a dose-dependent fashion with AMIN treatment.However, suppression was slight at pharmacological doses, with the decreased LAK activity being restored to normal ranges by IFN-α administered at the effector phase.No Suppression was observed at pharmacological doses with PROC or AZPT treatment.3. NK cell related surface markers (Leu-7, Leu-11 and OKM-1) showed no changes during treatment with AMIN at pharmacological or higher doses.4. The decreased NK activity observed in asthmatic children was correlated with the increased serum concentration of theophylline.
日本小児アレルギー学会の論文