タイトル無し

概要

論文の詳細を見る
We recently utilized continuous intravenous isoproterenol infusion in the treatment of respiratory failure in a 10-yr-old severely ill asthmatic boy. He had been frequently recieved intravenous aminophyllines since early life, bad not experienced cardiac complications. The patient responded to this therapy within 30nin. The maximum isopreterenol dosage administered was 0.167μg/kg/min and total dose was 1.52mg in the 32 hours.With tapering of isoproterenol, respiratory failure relapsed 2 times.Two hours after the isoproterenol was stopped, the patient experienced a vague chest pain. At that time ECG revealed ST segment elevations.Serum creatinine phoshokinase level elevated to 460IU/L and cardiac-specific CPK isoenzyme (CPK2=CPK-MB) was noted. We thought thet these findings were related to the effects of isoproterenol or the combination of isoproterenol and aminophillin on the myocardium. CPK returned to normal within two days and ECG also within 3 weeks.It's conclusive that this case was so called catecholamine myocarditis.This case suggests that careful cardiac monitoring is essential in the management of the patient receiving isoproterenol for the treatment of respiratory failure secondary to status asthmatics.
日本小児アレルギー学会の論文