Growth and Development after Treatment for Acute Lymphoblastic Leukemia. A Case Report in Identical Twins.
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概要
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Growth and development in a boy with acute lymphoblastic leukemia (ALL) were studied by comparing with his monozygotic twin brother who has been healthy for the whole observation period. The patient was diagnosed as having high-risk ALL at 10 years of age. Subsequently, he was treated with Childrens Cancer & Leukemia Study Group (CCLSG) High Risk 874 protocol, including 24 Gy cranial irradiation. The therapy was successfully completed when he was 13 years old. Since then, he has been in complete remission and now he is 17 years old. The physical growth of the patient was comparable to the Japanese standard. He was 171 cm tall at 17 years of age, while the brother was 182 cm tall. His testicular volume was 12 ml bilaterally, while the brother showed 27 ml. Pubertal voice change in the patient occurred 1 year later than in the brother. Serum gonadotropin levels in the patient were consistently higher than those in the brother. In contrast to these, there were no differences in their school performance and intelligent quotient. In this patient, physical growth was apparently normal, but was markedly retarded compared with his identical twin brother who seemed to be an ideal control.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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