Effective Conditioning of Donors for Granulocyte Transfusions with Recombinant Human Granulocyte Colony-Stimulating Factor.
スポンサーリンク
概要
- 論文の詳細を見る
Seven patients with hematologic malignancies were treated with granulocyte transfusions (GTX) for severe infection due to prolonged neutropenia. In the course of treatment, we performed 29 GTX. G-CSF was administered subcutaneously at a dose of 1, μug/kg to each GTX donor, 12 hours prior to leukapheresis in an attempt to increase the yield of granulocytes after informed consent was obtained. Leukapheresis techniques including hydroxyethyl starch (HES) was performed using Hemonetics model 50. Hydrocortisone was not administered. The mean volume of processed blood was lower (1.6-1.8 <I>l</I>) than that by conventional methods (2.4-3.7 <I>l</I>). The collecting time was also shortened. No side effects were seen in donors. The mean number of granulocytes collected was 2.54+1.2 × 10<SUP>10</SUP> which is about 3 times higher than that of the conventional method using hydrocortisone stimulation. In conclusion, G-CSF was safe to administer to normal individuals, and significantly improved the quantity of neutrophils collected. This study indicates that GTX donors and patients benefit from G-CSF administration to the donor prior to leukapheresis.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
- The Parent's Emotional Adaptation to the Children's Malignant Disease
- Side Effect of Cranial Radiation in Childhood Acute Leukemia
- Red Blood Cell Volume Distribution Width in Normal Children and in the Patients with Various Kinds of Hematological Disorders.
- Effective Conditioning of Donors for Granulocyte Transfusions with Recombinant Human Granulocyte Colony-Stimulating Factor.
- Two Infant Girls of CNS Leukemia with Chronic Subdural Hematoma