Combined Effect of Granulocyte Colony-Stimulating Factor and Macrophage Colony-Stimulating Factor on Allogenic Bone Marrow Transplantation.
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We examined the combined effects of granulocyte colony-stimulating factor (G-CSF) and macrophage colony-stimulating factor (M-CSF) on CPU-GM colony and recovery of granulocyte count after allogenic bone marrow transplantation. Admixture of G-CSF and M-CSF increased the number of CFU-GM colonies (139 ± 61.7) to a greater extent than admixture of G-CSF (66.7 ± 38.8) or M-CSF (64.6 ±27.9) alone. Moreover, the numbers of CPU-GM stimulated by G-CSF and M-CSF together were greater than the sum of CFU-GM stimulated by G-CSF and M-CSF alone. When G-CSF and M-CSF were administered together after allogenic bone marrow transplantation, the granulocyte count recovered by day 11. These data suggested that G-CSF and M-CSF may be administered simultaneously when prompt recovery of granulocytes is required.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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