Cytomegalovirus-Associated Hemophagocytic Syndrome in a 7-Week-Old Infant Presenting with Acute Renal Failure at the Early Stage.
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概要
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A 7-week-old boy suffered from fever of unknown origin, followed by aseptic meningitis, liver dysfunction, and acute renal failure. On admission, anuria due to acute renal failure, exanthema, and hepatomegaly appeared. His peripheral blood counts showed pancytopenia as follows : WBC 1, 600/μl. Hb 9.0 g/ dl, PLT 9.6×10<SUP>4</SUP>/μl. The bone marrow examination revealed an increase of hemophagocytic histiocytes with mature forms. The serum ferritin level was elevated to 4, 232 ng/ml. The virus antibody titer suggested cytomegalovirus infection. The diagnosis of cytomegalovirus-associated hemophagocytic syndrome (CMVAHS) was made. Complete remission was obtained after CAPD (continuous ambulatory peritoneal dialysis) and γ-globulin administration following exchange transfusion. The-renal dysfunction, which is reported to be caused by TNF and/or IL-2, is one of the poor prognostic factors. Of particular interest is that a 7-week-old infant with CMV-AHS developed acute renal failure at the early stage without other organ failures.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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