Serum Thymidine Kinase as a Possible Index of Peripheral Blood Stem Cell Harvest.
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概要
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We investigated serum thymidine kinase (s-TK) activity sequentially in five children with non-Hodgkin's lymphoma, neuroblastoma and acute lymphoblastic leukemia, who had been treated with high-dose chemotherapy before harvesting peripheral blood stem cells. s-TK activity showed low levels after chemotherapy, then increased rapidly. A significant correlation was found between s-TK activity and CD34 positive cell count. s-TK activity and CD34-positive cells increased to a maximum level when the white blood cell count increased to 5, 000-15, 000/μl. It was suggested that s-TK levels reflect proliferation of hematopoietic stem cells, and s-TK may be an index of peripheral blood stem cell harvest.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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