A Case of Severe Aplastic Anemia Transplanted from HLA Mismatched Bone Marrow Donor after Frequent Transfusions.
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We report a 12-year-old boy with severe aplastic anemia who underwent allogenic bone marrow transplantation from HLA one antigen mismatched his sister. He failed to respond to the other therapies, including immunosuppressive agents and cytokines, and required frequent transfusions. He was conditioned with cyclophosphamide 50 mg/kg/day for 4 days and total body irradiation 3 Gy. Cyclosporin A and short-term methotrexate were used for GVHD prophylaxis. He had full engraftment, the time to reach an absolute granulocyte count >500/μl, a reticulocyte > 1% and a platelet count >2 × 10<SUP>4</SUP>/μl were 25 days, 27 days and 28 days after transplantation, respectively. Although the patient developed acute GVHD of grade II, he showed marked improvement on methylprednisolone pulse therapy. The authors believe that, in children with severe aplastic anemia, bone marrow transplantation from HLA one antigen mismatched family donors should be performed, if the other therapy is not effective.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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