A High Serum Level of Interleukin-6 Associated with Clonal Evolution in a Patient with Burkitt's Lymphoma.
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A 6-year-old girl was admitted to our hospital for evaluation of abdominal mass. Masses in the bilateral kidney, ovary and the left mandibular regions were detected by computed tomography. The bilateral ovarian tumors were surgically excised and the pathological finding was compatible with Burkitt's lymphoma. An immunophenotyping analysis disclosed that the tumor cells were positive for CD 19, CD20, HLA-DR and s-IgM. Cytogenetic study of the ovarian tumor showed 46, XX, t (8 ; 14). She was treated with TCCSG B-8102 protocol, but there was no significant response. After 5 months, the leukemic conversion occurred and the patient died 6 months after admission. The examination of leukemic cell surface markers showed that the expression of CD 10, L29 and s-Igk were acquired, and indicated that blast cells acquired the immunological differentiation. The serum level of LDH, C-reactive protein (CRP) and interleukin-6 (IL-6) related to the aggressiveness of the disease. High activity of IL-6 was detected in supernatant of short-term cultured tumor cells, suggesting that the tumor cells produced IL-6 which reflected the clinical course.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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