A Case of t(1;19) Acute Lymphoblastic Leukemia with Reversible Methotrexate-Related Leukoencephalopathy.
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We report a case of acute lymphoblastic leukemia (ALL) with leukoencephalopathy which developed during high-dose methotrexate (MTX) and administration of intrathecal MTX in early first remission. He was successfully treated with high-dose leucovorin. A 10-year-old boy presenting with fever and hepatosplenomegaly was diagnosed as having ALL with 1;19 translocation. Complete remission was achieved with the high risk ALL protocol of our department. During early first remission, vomiting and semicoma developed following 3 g/m<SUP>2</SUP> MTX with intrathecal administration of 12 mg MTX. Magnetic resonance imaging (MRI) demonstrated hyperintensity lesions in T2-weighted imaging. High-dose intravenous leucovorin therapy was initiated and these symptoms recovered within 10 days. Intensive leucovorin therapy may be effective for acute leukoencephalopathy caused by high-dose MTX.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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