Successful Treatment with Erwinia L-asparaginase for Two Patients with Acute Lymphocytic Luekemia.
スポンサーリンク
概要
- 論文の詳細を見る
We report two patients with acute lymphocytic leukemia (ALL) who could not tolerate L-asparaginase (L-ASP) because of anaphylaxis, but could tolerate Erwinia L-asparaginase (E. L-ASP) well. Patient 1. A 12-year-old boy with ALL was begun on induction chemotherapy with VCR, PSL, ADR and L-ASP. On week 15 of induction therapy, following an intramuscular injection of L-ASP, he developed an anaphylactic shock. The L-ASP was discontinued thereafter. One year after diagnosis, he had a marrow relapse. Second complete remission was attained and he underwent PBSCT. Six months later he had a marrow relapse again. He successfully underwent reinduction therapy with VCR, PSL, mitoxantrone and E. L-ASP. Subsequently he received autologous bone marrow transplantation while he was in the 3rd complete remission period. Patient 2. A 2-year-old boy with ALL was begun on induction chemotherapy with VCR, PSL and L-ASP. Three years later, he experienced testicular relapse and underwent reinduction chemotherapy with VCR, PSL, ADR and L-ASP. On week 15 of reinduction therapy, his intradermal skin test against L-ASP showed a severe skin reaction. The L-ASP was discontinued thereafter. Two years later, he had a marrow relapse. Third complete remission was attained after continuous infusion of mitoxantrone. After several courses of intensification therapy with VDS, PSL, DNR and E. L-ASP, he received allogeneic bone marrow transplantation while he was in the 3rd complete remission period.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
- The Parent's Emotional Adaptation to the Children's Malignant Disease
- Side Effect of Cranial Radiation in Childhood Acute Leukemia
- Red Blood Cell Volume Distribution Width in Normal Children and in the Patients with Various Kinds of Hematological Disorders.
- Effective Conditioning of Donors for Granulocyte Transfusions with Recombinant Human Granulocyte Colony-Stimulating Factor.
- Two Infant Girls of CNS Leukemia with Chronic Subdural Hematoma