Efficiency of Erythrocyte Zinc Protoporphyrin/Heme Ratio in Classifying Microcytic Anemias.
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概要
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Microcytic anemias are commonly encountered in clinical medicine and are frequently caused by disorders of heme synthesis [usually iron deficiency anemia (IDA) or anemia of chronic disease (ACD)]. Using the clinical history, standard laboratory tests and in some cases stainable bone marrow iron, we divided 56 children with microcytic anemia (Hb ≤ 11.0 g/dl and MCV ≤ 81 fl) as follows : 20 ACD, 11 ACD with iron deficiency and 25 IDA. The efficacy of iron parameters [MCV, MCH, MCHC, serum iron, unsaturated iron binding capacity, transferrin saturation, serum ferritin (Fr) and erythrocyte zinc protoporphyrin/heme ratio (ZPP)] was evaluated by how properly they classified microcytic anemias into iron deficient (IDA and ACD with iron deficiency) vs. non-iron deficient one (ACD). 89.3% of iron deficiency can be detected by Fr, 92.9% by ZPP and 94.4% by the combination of Fr and ZPP. Because of reliability and ease of measurement, we recommend the hematofluorometer ZPP as one of the best parameters to discriminate microcytic anemias.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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