Trilinage Recovery of Hematopoiesis in Severe Aplastic Anemia by the Combination of G-CSF, Erythropoietin and Oxymetholone.
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概要
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A 13-year-old boy was admitted for the investigation of pale face and ecchymosis. According to remarkable pancytopenia in peripheral blood and hypoplastic bone marrow, the patient was diagnosed as severe aplastic anemia (SAA). Since methylprednisolone-pulse therapy was not effective and he hadno HLA-matched sibling, he was treated with recombinant granulocyte-colony stimulating factor (G-CSF), recombinant erythropoietin (Epo) and oxymetholone. Immediately, absolute neutrophil count increased to 3, 000/μ1. Three months later, also reticulocyte counts increased to 150, 000/, μ1 and he requiredno further red cell transfusion. Moreover, platelet counts reached 50, 000/μ1 five months after the start of treatment. At present, only G-CSF and Epo are administered once a week, and his peripheral blood and bone marrow findings are retaining within almost normal values. Even though it cannot be determined which drug was the most effective, we believe that this combination therapy is valuable to try for patients with SAA who have no bone marrow transplantation donors.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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