The Study of Hematological Recovery and Appropriate Timing for Marrow Harvesting in Autologous Bone Marrow Transplantation for Neuroblastoma.
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概要
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This study consists of 19 neuroblastoma cases that were treated with autologous bone marrow transplantation (A-BMT) involving marrow purged by magnetic immunobeads. To decide the timing of marrow harvesting, which appeared to increase the rate of hematological recovery, these cases were retrospectively studied regarding the relationship between the process of hematological recovery and the data of the peripheral blood at marrow harvesting and the number of infused stem cells. At the time of marrow harvesting, the white blood cell (WBC) and the neutrophil, the platelet were 4, 452 ±1, 963/, μl, 2, 154 ± 1, 460/μl, 24.5±7.4 × 10<SUP>4</SUP>/μl respectively. The number of CFU-GM colonies per mononucleated cells tended to decrease among cases that received chemotherapy in excess of 6 months compared with cases that received less than 6 months of chemotherapy. There was strong correlation between the number of infused mononucleated cells and the number of infused CFU-GM colonies in the group that received less than 6 months chemotherapy. This correlation was not found to exist in the group that received more than 6 months of chemotherapy. In the group receiving more than 5.0 × 10<SUP>4</SUP>/kg of CFU-GM, the recovery rate of the WBC counts and the neutrophil counts occurred sooner than in the group that received less than 5.0 × 10<SUP>4</SUP>/kg of CFU-GM. However, the platelet's recovery rate was not influenced by the number of infused CFU-GM colonies. In addition, receiving more than 5.0 × 10<SUP>4</SUP>/kg of infused CFU-GM appeared to shorten the duration of the fever experienced in each of these cases. In the use of A-BMT for neuroblastoma, our findings suggest that the harvesting of bone marrow be done as early as possible after obtaining complete remission and it appears to increase the rate of hematological recovery.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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