A Case Report of Acute Lymphoblastic Leukemia with Translocation t(4;11) and t(9;22) in a Teen-Age Girl.
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Clinical and laboratory features of a patient with acute lymphoblastic leukemia are presented. A 13-year-old girl presented a few weeks history of fatigue and anemia. White blood cells were310×10<SUP>4</SUP>/l consisting of 5% neutrophils and 95% blasts. The bone marrow aspirates were hypercellular and replaced by 91.7% L2 lymphoblasts which were negative for myeloperoxidase and non-specific esterase. Surface marker analysis revealed that leukemic cells expressed CD22, CD19 and CD38 antigens, but not CD10 antigen. The patient's leukemic cells had both the t (4 ; 11) and t (9 ; 22) chromosomal translocations. Gene rearrangement of Ig heavy chain was demonstrated, but Ig light chain and beta-TCR gene rearrangement were not found. No rearrangement of bcr3' and bcr5' was identified. Complete remission was achieved after 4 weeks induction therapy. After three months of chemotherapy she relapsed. In spite of reinduction therapy, the patient did not respond considerably and died 2 months later. To our knowledge, this is the first case having two chromosomal translocations t (4 ; 11) and t (9 ; 22).
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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