Successful Bone Marrow Transplantation for a Child with Hepatitis-Associated Aplastic Anemia from an HLA DR Mismatched 7-Month-Old Brother.
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Several studies using alternative donors have been carried out to improve the survival rate in patients with severe aplastic anemia who do not have an HLA identical sibling. We report a 4-year-old male with heptitis-associated aplastic anemia who received an allogeneic bone marrow graft from an HLA DR mismatched 7-month-old brother. The patient was prepared with cyclophosphamide combinated with 500 cGy total lymphoid irradiation and 500 cGy total body irradiation. We used a combination of cyclosporin plus methotrexate for the prophylaxis of graft-versus-host disease (GVHD). Although the patient engrafted promptly, he developed acute GVHD (grade III), which was treated with high dose methylprednisolone. He has had full hematopoietic recovery and no signs of chronic GVHD for 16 months following bone marrow transplantation.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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