A Case of ALL with Transient Hyperlipemia due to L-Asparaginase Administration.
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An 11-year-old boy was admitted to our department for testicular relapse of ALL. Testicular irradiation and reinduction therapy according to PVDA III regimen were administered and severe hyperlipemia of type V (WHO Classification) developed during a two-week course of L-asparaginase (10000 IU/m<SUP>2</SUP>/day). When the patient was given reinforcement chemotherapy including L-asparaginase, he showed remarkable hyperlipemia again. The serum triglyceride reached 9, 208 mg/dl and LDL apheresis was performed. Plasma lipoprotein disk electrophoresis disclosed a marked increase in the VLDL fraction and a decrease in the LDL fraction. Plasma level of apo-lipoprotein C-III fraction, which is considered to inhibit lipoprotein lipase (LPL), increased remarkably. We observed that the administration of L-asparaginase made no significant change in the plasma activity of LPL and tended to decrease the plasma activity of hepatic triglyceride lipase (HTGL). HTGL is generally considered to catabolize chylomicron remnant and IDL. It suggested that HTGL played some part in this abnormality of fat metabolism
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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