Peripheral Blood Stem Cell Transplantation for the Treatment of 26 Children with Acute Lymphoblastic Leukemia with Delayed Induction or Relapse.
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概要
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Twenty-six children (1-16 y ; median, 8y) with acute lymphoblastic leukemia (ALL) underwent high-dose chemotherapy without total body irradiation and autologous peripheral blood stem cell transplantation (PBSCT). Five patients with delayed initial induction underwent PBSCT in the first complete remission (CR) after second-line induction therapy. Twelve patients underwent PBSCT in the second CR, and 4 in subsequent remission (advanced CR). Five patients were treated at refractory relapse. After PBSCT, the median number of days required to achieve a white blood cell count of 1000/μl, a granulocyte count of 500/ μl and a platelet count of 5 × 10<SUP>4</SUP>/μl were, respectively, 13, 13, and 16. Fifteen patients developed relapse of the leukemia, but the remaining 11 patients are surviving disease-free for 2 to 56 months posttransplant. The data justify the incorporation of PBSCT in the treatment of children with ALL associated with high-risk features.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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