Effect of Recombinant Human Growth Hormone (rhGH) on the Colony-Forming Unit Granulocyte/Macrophage (CFU-GM) in Human Umbilical Cord Blood.
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The effects of recombinant human growth hormone (rhGH) on the colony-forming unit granulocyte/macrophage (CFU-GM) in human umbilical cord blood were studied. In conventional semisolid cultures, rhGH had no effect on CFU-GM. However, in serum-free liquid cultures, CFU-GM increased by the addition of rhGH under the presence of rhIL3. Furthermore, increased proliferating cell nuclear antigen (PCNA) -positive cells were observed in the presence of rhGH. A good correlation between the total number of CFU-GM in liquid culture and PCNA-positive cells ratio was observed. These results suggest that rhGH might promote the proliferation and differentiation of hematopoietic stem cells into CFU-GM.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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