Megakaryoblastic Leukemia after Transient Abnormal Myelopoiesis in a Boy with Down Syndrome.
スポンサーリンク
概要
- 論文の詳細を見る
We report a boy with Down syndrome who had transient abnormal myelopoiesis (TAM) (transient myeloproliferative disorder) during the neonatal period, followed by megakaryoblastic leukemia at 31 months of age. At birth, the peripheral white blood cell count was 28, 600/μl, 1 with 42.8% blast cells, and the bone marrow aspirate with 22.7% blast cells. By 3 months of age, blast cells disappeared without treatment from the peripheral blood. At age 26 months, the blast cells reappeared in peripheral blood. At age 31 months, the white blood cell count was 47, 700/μl, 1 with 93.5% blast cells. The blast cells were positive for both platelet peroxidase and platelet-associated antigens (pl-gp Ib and pl-gp IIb/IIIa). The karyotype of the blast cells was 47, XY, +21, del (20) (q13). The patient was treated with a low-dose cytosine arabinoside, adriamycin and etoposide but no remission was attained, and he died at age 38 months. Sequential Q- and R-banding analysis demonstrated duplication of a paternal chromosome 21 in two of the three chromosome 21.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
- The Parent's Emotional Adaptation to the Children's Malignant Disease
- Side Effect of Cranial Radiation in Childhood Acute Leukemia
- Red Blood Cell Volume Distribution Width in Normal Children and in the Patients with Various Kinds of Hematological Disorders.
- Effective Conditioning of Donors for Granulocyte Transfusions with Recombinant Human Granulocyte Colony-Stimulating Factor.
- Two Infant Girls of CNS Leukemia with Chronic Subdural Hematoma