A Case of Idiopathic Severe Aplastic Anemia Treated Mainly with Cyclosporin A.
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概要
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A case of idiopathic severe aplastic anemia treated mainly with cyclosporin A is described. A 13-year-old boy was admitted for dizziness, pale face, and petechia on the extremity. His blood counts were as follows : white blood cells 2, 200/μl (neutrophil 23%); red blood cells 1.62×10<SUB>6</SUB>/μl; hemoglobin 5.5 g/dl; platelets 1.8×10<SUB>4</SUB>/μl. These hematological examinations showed pancytopenia. The results of his bone marrow aspiration were as follows : nuclear cells 32, 000/μl; megakaryocytes less than 6.25/, al. He was revealed to have fatty bone marrow. There was no colony formation of erythrocytic series and granulocytic series from his bone marrow cell culture. So he was diagnosed as having idiopathic severe aplastic anemia. As we could not find an adequate donor for the bone marrow transplantation, medication was started. He was successfully treated with cyclosporin A. It was found to be useful reducing the frequency of blood transfusions. And his condition took a turn for the better. The side effects were hirsuteness and reversible kidney trouble. rhG-CSF was used to prevent infection, and the use of erythropoietin was administered to decrease the amount of blood transfusions. Now, it has been about 2 years since he became ill. He can spend his daily life as usual, and the interval between blood transfusions has been much longer than before.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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