Studies on Thrombopoiesis in Kawasaki Disease.
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概要
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Regulation of thrombopoiesis was studied in Kawasaki disease (KD). Serum levels of CRP and IL-6 were markedly elevated in the first week of the disease and then rapidly reduced in the second week. Although there was no increase of platelet counts in the first week, a sharp increase of it occurred after reduction of IL-6, up to the maximal level in the second week, and then the counts gradually declined through the third week and later. CFU-Meg was cultured in the medium with the addition of PHA-LCM derived from patients with KD. The relative activities to control PHA-LCM were 1.28±0.20 in the first week, 1.62±0.36 in the second week, 1.58±0.40 in the third week, 0.93±0.20 in the fourth week and 1.22±0.13 in the fifth week concomitantly, showing a peak level in the second to third weeks. To study the activity of the inhibitory factors in thrombopoiesis, IL-3 was added to be the maximal optimal-concentration to the cultured cell line of CFU-Meg, and this was cultured. Count of colony was low in the first week, but increased in the second week, and remained to be a certain level in the third week and later. This might suggest that the inhibitory factors were most potent in the first week and then gradually diminished. It was suggested that IL-6, Meg-CSF (principally, IL-3) and their inhibitors are involved in the change of platelet counts in KD.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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