Inhibition of Granulopoiesis by T-lymphocytes in a Case of Infantile Genetic Agranulocytosis (Kostmann Type).
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A case of infantile genetic agranulocytosis (Kostmann type) was reported and the mechanism of impaired granulopoiesis was evaluated. Peripheral blood mononuclear cells obtained from this patient suppressed both autologous and allogeneic granulocyte-macrophage (GM) colony formation. GM-colony formation was augmented by the treatment of T-cell depletion from the patient's bone marrow mononuclear cells. Neither autologous nor allogeneic GM-colony formation were suppressed by patient's serum. These findings suggested that T-cells played an important role in the pathogenesis of Kostmann-type neutropenia of this patient.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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