A Case of 7-Monosomy Myelodysplastic Syndrome Transformed from Severe Aplastic Anemia after a 3-Years Course in Conjunction with Recombinant Human Granulocyte Colony-stimulating Factor(rhG-CSF) Treatment.
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A cases of severe aplastic anemia (SAA) that transformed to myelodysplastic syndrome (MDS) with 7-monosomy and finally to acute leukemia is presented. The patient was first diagnosed as SAA at 5 years of age in October 1986. He did not respond to various conventional treatments. In May 1989, when he had severe infection he received high-dose rhG-CSF (KRN 8601 up to 1, 200 μgl m<SUP>2</SUP>) for 8 weeks. There was a remarkable monocytic response, but it fluctuated thereafter. In November his bone marrow showed normal cellularity with 12.6% myeloblasts, which is comparable to MDS. Chromosomal analysis revealed 48, XY, -7, +10, +21, +22. At the beginning of 1990 MDS changed into overt leukemia and he expired in April. It is unclear whether he had clonal abnormality since the onset of aplastic anemia or additional clonal abnormality induced by such treatments as androgen, antilymphocyte globulin (ALG), and rhG-CSF. There is a good chance that the rhG-CSF switched on the development and growth of the 7-monosomy clone in this patient.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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