Intracerebellar tumor in a child with acute lymphoblastic leukemia.
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概要
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A 4-year-old boy was diagnosed as having acute lymphoblastic leukemia (ALL, L1 by FAB) in June, 1982. The immunological phenotype showed CD 10<SUP>+</SUP> ALL. The patient received standard combination chemotherapy, prophylactic intrathecal methotrexate, and whole-skull irradiation. The initial complete remission was interrupted by his first hematological relapse in 1984. The patient subsequently relapsed with central nervous system leukemia (CNSL) in 1987, when he was treated with chemotherapy and intrathecal methotrexate and attained the third complete remission. In 1989, the patient relapsed again at the testicles and CNS. Systemic chemotherapy and intrathecal methotrexate were continuously given ; however, the patient complained of headache, vomiting, and gait disturbance 10 months later. Computed tomography (CT) and magnetic resonance imaging (MRI) demonstrated a tumor in his right cerebellar hemisphere with secondary hydrocephalus. The patient was histologically diagnosed as having a tumor which consisted of leukemic cells negative for CD10. This rare complication of ALL indicates that MRI is useful for the diagnosis of intracerebellar infiltration of leukemic cells, and that phenotypic change of leukemic cells may have a relationship with the development of intracranial tumor.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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