Severe aplastic anemia remarkably improved by cyclosporin A: A case report.
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A 8-year-old boy with severe aplastic anemia responded to cyclosporin A (CyA) alone. He was admitted to our department, with the complaints of pale face and subcutaneous hemorrhage. Peripheral blood examination showed RBC 128×10<SUP>4</SUP>/μl, WBC 2, 100/μl, granulocytes 252/μl, platelets 11, 000/μl, and reticulocytes 20, 000/μl. Bone marrow aspiration revealed hypocellularity. Bolus methylprednisolone therapy followed with no hematological improvement. Two months after hospitalization, oral administration of CyA at a dosage of 5 mg/kg/day was initiated without support of any other therapeutic modalities. Since the treatment produced no hematological response, after 5 weeks the dosage was increased to 10 mg/kg/day. Following the increase in dosage, hematological conditions showed gradual improvement but the development of renal dysfunction forced a reduction in dosage back to 5 mg/kg/day after 7 weeks. In spite of the dosage reduction, the tendency toward an increase in blood cells continued. Twelve months after the start of CyA therapy, the following results were obtained : Hb 11 g/dl, neutrophils over 1, 000/, al, and platelets over 30, 000/μl. CyA administration was interrupted after 12 months but at present (8 months since the cessation of drug administration), no pancytopenic tendency was recognized.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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