Myelodysplastic syndrome with monosomy 7 in a child, terminating in erythroleukemia.
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概要
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There are some reports describing preleukemic patients with monosomy 7. Recently we had an interesting patient with monosomy 7 who developed erythroleukemia after 1 year and 9 months since the initial presentation. The patient, a 4-year-1-month-old boy, was diagnosed as myelodys-plastic syndrome because of blast cells in both peripheral blood and bone marrow. At this time, chromosome analysis of blast cells showed 45XY, -7 and he was diagnosed as monosomy 7 syndrome. He developed erythroleukemia (FAB; M6) after 1 year and 9 months. At this time, chromosome analysis also showed 45XY, -7. He was treated with low-dose Ara-C but died of aspergillus pneumonia. It is well known that monosomy 7 syndrome is a preleukemic state which develops ANLL on its course, but it is rare that this syndrome terminates in erythroleukemia.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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