Analysis of surface antigen on lymphoid malignancies in children.
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概要
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Surface antigens on 227 cases of acute lymphoblastic leukemia (ALL) and 32 cases of non-Hodgkin's malignant lymphoma (NHL) in children were analyzed using a panel of monoclonal antibodies. By immunological criteria, ALL cases were subdivided into 4 major subgroups : common ALL (176 cases); T-cell ALL (14 cases); B-cell ALL (4cases); undifferentiated-type ALL (33 cases). T-cell associated antigens (CD3, CD5, and CD7) were exclusively expressed on T-cell ALL/NHL. On the contrary, B-cell associated antigens (CD19, CD20, and P20 antigen) were demonstrated on the cell surface of common ALL, undifferentiated-type ALL, and B-cell ALL/NHL but not on T-cell ALL/ NHL. Both common ALL cases and undifferentiated-type ALL cases could be subdivided into phenotypically defined subgroups on the basis of CD9, CD10, P20 antigen, and HLA-DR antigens. Cytoplasmic μ chain and CD20 were positive in 16 of 78 cases (20.5%) and 17 of 133 cases (12.8%) of common ALL, respectively. However, no positivity was noted in a group of undifferentiated-type ALL.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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