Bone marrow transplantation in three children with advenced neuroblastoma.
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概要
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Since April 1985, 8 children with advanced (stage III, IV) neuroblastoma consecutively entered an aggressive protocol, including chemotherapy and radiation therapy, and 3 of 7 cases received bone marrow transplantation (BMT) in our institute. Of these 3 cases, one patient received allogeneic bone marrow from his HLA-identical brother (Patient 1) and two patients underwent autologous BMT (Patients 2 and 3). The first patient underwent transplantation after preparation with melphalan and total-body irradiation, and short-term methotrexate and cyclosporin A were administered to prevent graft-versus-host disease. He died on day 26 after grafting due to renal tubular injury. Patient 2 was transplanted with unpurged autologous marrow after preparation with melphalan and VP-16. She is now well 30 months after transplantation. Patient 3 was transplanted with unpurged autologous marrow which was cryopreserved for 2 years. Melphalan and total-body irradiation were employed for preconditioning in this transplantation. Engraftment was achieved but hematological recovery was delayed. She relapsed 2 months after transplantation and died 3 months later. In the comparison of transplanted and untransplanted cases, we suggested there is an overall advantage in BMT for patients with advanced neuroblastoma, but the timing of transplantation and the method of preconditioning are controversial.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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