Constitution and Distribution of Polyamine Family in Circulating Blood of Healthy Children
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概要
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The present study was carried out to identify the constitution and distribution of the polyamine family in peripheral blood of growing children. Free and conjugated polyamines were investigated in erythrocytes and plasma from 103 healthy children. As a reference, the same amines were also determined in 9 adult volunteers. In summarizing the results of this study, the following evidences were elucidated as characterizing polyamine metabolism in growing children : (1) free polyamines, especially free spermidine in circulating blood, mostly compartmentalized in erythrocytes; (2) higher amount of total polyamines in whole blood, free putrescine in erythrocytes and plasma, free and conjugated spermidine in erythrocytes in the circulating blood. These results of distibution of polyamines in peripheral blood indicated that erythrocyte polyamine levels are mainly related to the fluctuation of polyamine levels in circulating blood. The present evidence also suggests that the enhanced polyamine synthesis in children derives from a large amount of free putrescine from ornithine de novo, as well as that reproduced from N<SUP>1</SUP>-acetylspermidine via the degradation pathway.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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