Treatment Result in High-Risk ALL Protocol for Relapsed Childhood Acute Lymphoblastic Leukemia
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The prognosis for children with acute lymphoblastic leukemia (ALL) in relapse has been dismal. In this study we have treated 22 such patients with an intensive combination chemotherapy (High-risk ALL protocol, Mie University) including six drugs (Vincristine, Bleomycin, Methotrexate, Endoxan, Adriamycin, Predonine) for remission induction and with rotation of eight drugs (Vincristine, Bleomycin, Methotrexate, Endoxan, Adriamycin, Predonine, 6-Mercaptopurine, Hydroxyurea) to maintain remission. A second complete remission was induced in 15 (75%) of the 20 children with ALL in bone marrow (BM) relapse. However, early BM relapses were observed in 9 of 15 responders. Leukemic children whose prior complete remission lasted less than 36 months had significantly poorer responses to retreatment than did those with a longer prior remission (<I>p</I><0.01). Moreover, prognosis of children in second or third BM relapse was significantly poorer than that in first BM relapse (<I>p</I><0.05). We concluded that High-risk ALL protocol would be effective in inducing second complete remission but its duration has been short.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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