Biphenotypic Leukemia, Initially Presented as Common ALL and the Blasts Expressed Peroxidase Activity and Myeloid Antigens at Relapse : A Case Report
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We describe a 4-year-old boy with biphenotypic leukemia. At the onset of the disease, he was diagnosed as FAB-L1 and non-T, non-B ALL (common ALL), on the basis of morphology of small lymphoblastoid cells negative for peroxidase staining (PDX) on the bone marrow smear, and marker profiles (Ia<SUP>+</SUP>, CD 10<SUP>+</SUP>, CD5<SUP>-</SUP>, CD 13<SUP>-</SUP>, and E rosette<SUP>-</SUP>). Complete remission was achieved by TCLSG 10th, ALL standard risk protocol. However, relapses were observed at 17, 26, and 31 months after the first remission. At the third relapse, PDX<SUP>+</SUP> large blasts appeared in bone marrow together with PDX-small blasts. The surface marker analysis revealed the blasts with Ia<SUP>+</SUP>, CD 10<SUP>+</SUP>, CD 19<SUP>+</SUP>, and CD 13<SUP>+</SUP>. By double staining with CD 19 and CD 13, about 30% of the blasts reacted to both antibodies. As indicated in this case, biphenotypic leukemias may exist among early relapsed ALL, and surface marker analysis should be repeated in detail for detecting such type of leukemias.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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