A Case of Chronic Myelogenous Leukemia Treated with Reduced-Intensity Stem Cell Transplantation from HLA-Identical Sibling
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We report a case of a 12-year-old boy with chronic myelogenous leukemia (CML) who received reduced-intensity hematopoietic stem cell transplantation (RIST) from a HLA identical brother. We initiated therapy with imatinib and achieved hematologic remission one month later. Molecular genetic remission was achieved after ten months. The donor for RIST was a younger brother who was HLA identical. Pretreatment was with fludarabine (total 125 mg/m<SUP>2</SUP>) + melphalan (total 200 mg/m<SUP>2</SUP>). The transplantation cell count was 2.47 × 10<SUP>8</SUP>/kg. For prevention of GVHD we used ciclosporin + short term methotrexate. Stomatitis of NCI-CTC grade 3 occurred as a transplantation-related complication and acute GVHD was grade II. However, there was no indication that it would becomechronic GVHD. It is now eleven months post transplantation and molecular genetic remission has been maintained. There are few reports of RIST for CML and the ranking of its applicability is unclear. However, as demonstrated here, RIST has low transplantation-related toxicity and little risk of late stage disorder for a young patient. We believe RIST is a transplantation method option if the conditions are properly prepared.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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