Unrelated Cord Blood Transplantation in Two Patients with Wiskott-Aldrich Syndrome
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概要
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We report two infants with Wiskott-Aldrich syndrome (WAS) that was successfully treated with unrelated cord blood transplantation (UCBT) from a human leukocyte antigens (HLA) one-locus mismatched donor. In case 1, an 8-month-old boy had cytomegalovirus infection. We could control the infection with ganciclovir and foscarnet prior to UCBT. He received a nucleated cell dose of 6.87 × 10<SUP>7</SUP>/kg. In case 2, a 4-month-old boy had mucous membrane lesions. He received a nucleated cell dose of 4.32 × 10<SUP>7</SUP>/kg. An absolute neutrophil count of 500 cells/μl was achieved on posttransplant days 22 and 26. A platelet count of 20, 000 cells/μl was achieved on posttransplant days 65 and 40. Both patients uneventfully engrafted and developed grade II acute graft-versus-host disease (GVHD) with no evidence of chronic GVHD. Normal mitogen response was achieved at 8 months and 10 months. Serum IgG levels remained within a normal range for the ages after discontinued intravenous immune globulin. Unrelatedcord blood can be an alternative source of stem cells for transplantation in children with WAS when a suitable HLA-matched sibling donor is not available.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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