Unrelated Cord Blood Transplantation of 22 Cases with Hematological Malignancies: A Single Institution Experience
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概要
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We evaluated 22 consecutive unrelated cord blood transplants (UCBT) for hematological malignancies in children at a single institute from 1999 to 2005. Six patients had UCBT as a second hematopoietic stem cell transplantation, and three patients had relapsed after the first UCBT. Median patient age was 9.5 years (range, 8 months-20 years), and median body weight was 36 kg (range, 8-64 kg). Most patients received a myeloablative conditioning regimen consisted of total body irradiation (fourteen patients) or busulfan (seven patients). Cord bloodgraft were 0-2 HLA antigen-mismatched with the recipient and contained a median cryopreserved cell dose of 4.3×10<SUP>7</SUP> nucleated cells per kilogram (range, 2.4-11.0×10<SUP>7</SUP>/kg). Twenty patients achieved neutrophil engraftment (median 22 days). Eight patients developed acute graft-versus-host disease (GVHD) grade III-IV. With median follow-up of 6.5 months, 9/19 patients (47.4%) are alive, and eight patients died of non-relapse causes. Notably, late neutrophil engraftment (more than 22 days) was associated with worse survival rates. Relapse was the major event for patients with late engraftment. Therefore, it is important to establish a suitable conditioning regimen to introduce rapid engraftment and GVHD prophylaxis for achieving high survival rates after UCBT in children.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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