A Case of Combined Autoimmune Neutropenia and Thrombocytopenic Purpura: Identification of Autoantibodies against Specific Antigens
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概要
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There have been few reported cases of autoimmune neutropenia combined with thrombocytopenic purpura with clearly identifiable autoantibodies against specific antigens. We here describe the case of 6-month-female with autoimmune neutropenia and thrombocytopenic purpura in whom we were able to identify autoantibodies against NA1 antigen of neutrophils, and GPIIb/IIIa and GPIb/IX antigens of platelets at her acute stage. Virologic studies including parvovirus B19, cytomegalovirus, and Epstein-Barr virus were all negative. Following treatment with 1 g/kg γ-globulin, platelet counts increased gradually and reached the normal level at 3 months. Neutrophil counts were refractory to the γ-globulin treatment, but they exceeded 500 /μl at 5 months, and the patient did not suffer from any serious infection by prophylactic administration of sulfamethoxazole and trimethoprim. A review of the Japanese literature revealed that the occurrence of autoimmune cytopenia has two age peaks, one at around 1 year and one after 10 years, and the latter cases tend to have certain underlying disorders.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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