Pathogenesis and Treatment of Acute Lymphocytic Leukemia in Infants
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概要
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Acute lymphocytic leukemia (ALL) in children less than one year of age is characterized by more organomegaly, higher WBCs, an increased incidence of CNS leukemia, a high frequency of chromosome abnormalities involving 11q23, and a poor (30%) event-free survival. Recent molecular studies have suggested mechanisms by which the 11q23 region is targeted. Moreover, gene expression studies suggest that infant ALL is not a homogeneous disease : there may be multiple causes even in infants with similar chromosome abnormalities. Therapeutically, two large multicenter trials (Interfant and Children's Oncology Group) suggest that a cure rate of 50-65% can be achieved using chemotherapy regimens that contain high dose methotrexate, etoposide and cyclophosphamide. In addition, new stem cell transplantation regimens have also showed improved outcomes for infants with ALL. Recommendations for treatment are presented based upon these new biologic and clinical findings.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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- Side Effect of Cranial Radiation in Childhood Acute Leukemia
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- Two Infant Girls of CNS Leukemia with Chronic Subdural Hematoma