Unrelated Cord Blood Stem Cell Transplantation Using Non-Myeloablative Regimen for Refractory Non-Hodgkin's Lymphoma
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概要
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We have performed an allogeneic umbilical cord blood stem cell transplant to an 12-year-old male patient with T-cell Non-Hodgkin's lymphoma (NHL). The NHL was refractory to conventional intensive chemotherapy. High-dose chemotherapy and radiation therapy was given, but the patient relapsed 3 times. He was then treated with allogeneic umbilical cord blood stem cell transplantation (CBSCT) using a fludarabine, and melphalan-based nonmyeloablative conditioning regimen. GVHD prophylaxis was composed of tacrolimus alone. The patient had neutrophil engraftment within 28 days. Investigation by short tandem repeat (STR) showed that 100% of his bone marrow nucleated cells were reconstituted by donor origin since day +28. He is now alive and well and remains disease-free 7 months after transplant. Although the symptom of GVHD is faint, we evaluated that the graft-versus-lymphoma effect is one of the factors contributing to his remission.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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