The Outcome of Children with Induction Failure and the Effectiveness of Salvage Therapy in CCLSG AML 9805 Protocol.
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概要
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We retrospectively analyzed the outcome of children who did not achieve remission with induction therapy and discussed the effectiveness of salvage therapy in CCLSG AML 9805 protocol. Seventy-five children were treated with CCLSG AML 9805 protocol from May 1998 to December 2001. Fifteen (20%) out of 75 failed to achieve complete remission with the induction regimen. Thirteen of these children were then treated with salvage protocol (9805 IF protocol) and 71% (10 cases) of them subsequently could achieve complete remission. Stem cell transplantation (SCT) was performed for 5 children during or after completing 9805 IF protocol and three of them are disease-free without complication. Three children were treated with IF protocol without SCT ; however, all of them developed bone marrow relapse within several months after completion of the chemotherapy. Two patients treated with protocols other than 9805 IF are disease-free after unrelated cord blood transplantation. Three-year event-free survival of fifteen cases who failed to achieve remission was 46.7% and that of thirteen cases treated with 9805 IF protocol was 38.5%. 9805 IF protocol was considered to an effective salvage therapy for AML children with induction failure. However, SCT is mandatory to maintain remission for these patients.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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