Successful Retransplantation from Another HLA-DR and-DQ Mismatched Sibling for Relapse after Fully Matched Bone Marrow Transplantation in a Patient with t(16 ; 21) (p11 ; q22) Acute Myelomoncytic Leukemia.
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An 8-year-old boy with t (16 ; 21) acute myelomonocytic leukemia (AMMOL) relapsed at 8 months after diagnosis during intensive consolidation chemotherapy. He underwent bone marrow transplantation (BMT) (HLA-A, B, C, DR, and DQ matched) from his eldest brother. Although engraftment was obtained, hematological relapse occurred 2 months later. Peripheral blood stem cell infusion and donor lymphocyte infusion were then performed from the same brother without causing acute graft-versus-host disease (GVHD) or achieving a second remission. Thereafter BMT (one allele mismatch for HLA-DR and DQ) was done by using his second elder brother as the donor, and remission was induced after grade II acute GVHD developed in the skin and in the gastrointestinal tract. These findings suggested that remission was induced by an adequate graft-versus-leukemia (GVL) effect because of the differences of HLA-DR and DQ between the patient and the second donor.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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