A Retrospective Analysis of Safety and Indication for Prophylactic Dialysis in Patients with Acute Leukemia or Non-Hodgkin's Lymphoma at High Risk of Renal Failure because of Tumor Lysis Syndrome.
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We evaluated the safety of peritoneal dialysis and continuous venovenous hemodialysis in patients with lymphoma or leukemia who have a risk of tumor lysis syndrome (TLS) at the time of presentation and initial therapy. Remission induction was achieved by support with dialysis in 11 of 12 patients. Some manageable complications occurred, and one death was a result of MRSA sepsis. We concluded that prophylactic dialysis was a safe procedure. We propose that these patients may be the subjects of prophylactic dialysis, having a huge tumor or advanced stage Burkitt's lymphoma, or both, who showed no decrease of serum uric acid concentration despite aggressive hydration, alkalinization, and administration of allopurinol, or who have hyperkalemia of more than 4.5 mEq/l at the time of presentation.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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