The Clinical Significance of a Preconditioning Regimen Containing Melphalan and the Use of Granulocyte Colony-Stimulating Factor for Stem Cell Transplantation in Childhood Acute Myeloid Leukemia.
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A multi-institutional study was performed to determine the clinical significance of a preconditioning regimen containing melphalan and the use of G-CSF for stem cell transplantation in childhood AML. From September 1994 to December 1996, sixty-eight patients (<20 years of age) with AML were enrolled. Patients in the first complete remission (CR1) were classified as standard-risk (SR, <I>n</I>=46) and received busulfan (Bu, 16 mg/ kg) +melphalan (180-210 mg/m<SUP>2</SUP>) in both the allogeneic (related, 27; unrelated, 2) and autologous (BMT, 14; PBSCT, 3) transplant setting. Patients in the CR2 or subsequent remission or not in CR were classified as high-risk (HR, <I>n</I>=22), and treated with TBI +melphalan, + etoposide, Bu, or thiotepa in various combinations. The disease-free survival (DFS) rate of the SR group was 73.5% (related BMT, 77%; ABMT, 64.3%) at 3 years, and that of the HR group was 36.4%. Regimen-related toxicity was acceptable in the SR group, but severe mucositis (40.8%) and veno-occlusive disease (18.2%) were observed in the HR group. No serious renal toxicity was observed. Sixty-five patients were eligible for a G-CSF study. G-CSF (300 μg/m<SUP>2</SUP>) was administered as a 1-h (14 patients) or 24-h (17 patients) infusion from day 3 or 5 post-transplant (G-CSF group); the remaining 34 patients did not receive G-CSF (non-G-CSF group). No difference occurred in the recovery of granulocytes after the 1-h and 24-h G-CSF infusion regimens, but a significant difference was noted between the G-CSF and the non-G-CSF groups. Moreover, the DFS rate in the G-CSF group was higher than in the non-G-CSF group. We conclude that a preconditioning regimen containing melphalan is feasible and that G-CSF administration is beneficial in the treatment of childhood AML.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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