Acute Myeloblastic Leukemia Complicated with Bronchiolitis Obliterans Organizing Pneumonia after Allogeneic Bone Marrow Transplantation.
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We report a 15-year-old boy who developed bronchiolitis obliterans organizing pneumonia (BOOP) 6 months after allogeneic bone marrow transplantation from an HLA-matched elder sister for acute myeloblastic leukemia during the refractory phase. We successfully confirmed engraftment 17 days after infusion of 5.8 X 10<SUP>8</SUP>/ kg mononuclear donor cells to the patient. The patient received cyclosporin A and short-term MTX for graft-versus-host disease (GVHD) prophylaxis. He showed grade I acute GVHD of the skin. We performed two courses of donor lymphocyte transfusion (DLT) to eradicate leukemic cells. The patient developed a nonproductive cough without signs of chronic GVHD 6 months after BMT. The results from the pulmonary function test, imaging study, and bronchoscopic lung biopsy were consistent with the diagnosis of BOOP. The patient was treated with oral prednisolone (1 mg/kg/day), and his clinical status and chest imaging findings improved dramatically after 2 weeks.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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