Genetic Background of Chemotherapy-Induced Unconjugated Hyperbilirubinemia.
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概要
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Chemotherapy for malignant neoplasms sometimes causes unconjugated hyperbilirubinemia without liver dysfunction. We examined the bilirubin UDP-glucuronosyltransferase gene (<I>UGT1A1</I>) from three leukemic patients in whom chemotherapy evoked a hyperbilirubinemic response. The gene of three patients revealed an identical heterozygous missense mutation in exon 1 (G71R). Thus mutation of <I>UGT1A1</I> may be the genetic cause of chemotherapy-induced unconjugated hyperbilirubinemia.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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