Significance of CD3 Antigen Expression in Childhood T-ALL/NHL.
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概要
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In leukemic blasts of childhood T-cell acute lymphoblastic leukemia/non-Hodgkin's lymphoma (13 cases of T-ALL/ 3 cases of NHL), we studied the expressions of CD3 antigen and of T-cell receptor (TCR) by using the flow cytometric assay and TCR gene rearrangements with Southern analysis. Data were evaluated in relation to the clinical features. CD3 was positive in 7 cases (5 ALL/2 NHL) and negative in 9 (8 ALL/1 NHL). WBC counts (median 152, 100/μl) at onset of the disease in the CD3-group were significantly higher than those (6, 400/μl) of the CD3 + group (<I>p</I>=0.016). The TCR was expressed in 6 (4 αβ, 2 γδ) of the 7 CD3 + patients. On the other hand, no TCR was expressed in the CD3-patients studied (6/7 vs. 0/3, <I>p</I>=0.01). The genotypes of TCR were compatible with phenotypes showing rearrangements of γ and β genes in the αβ type and those of the <SUB>γ</SUB> gene only in the γδ type in the CD3 + patients. Including the 3 cases in which the TCR was not phenotypically expressed, both γ and β genes were rearranged in 7 of 9 CD3-patients. Clinically, relapses were noted in only one case in the CD3+ group and in 5 cases in the CD3-group (1/7 vs. 5/9, <I>p</I>= 0.09). It seems that the leukemic blasts at different differentiation stages estimated from CD3 and TCR expressions may have an effect on the clinical features including prognosis in pediatric patients with T cell malignancy ; however, further studies with a large number of patients are required to confirm our observation.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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