Invasive Aspergillosis of Posterior Nasal Cavity and Paranasal Sinuses Developed during the Induction Therapy for Acute Lymphoblastic Leukemia. A Report of a Girl Cured by Antifungal Agents and Surgical Debridement.:A Report of a Girl Cured by Antifungal
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We report a 7-year-old girl with acute lymphoblastic leukemia who developed invasive aspergillosis of posterior nasal cavity and paranasal sinuses. During induction chemotherapy, fever that had once subsided as a result of antibiotics recurred with an elevation of CRP, and an ulcer (1 × 1 cm) of soft palate mucosa was noted. Based on the findings of computed tomography and a biopsy specimen from the soft palate, a diagnosis of invasive mycosis of the posterior nasal cavity and paranasal sinuses was done, and an intravenous administration of amphotericin B (AMPH-B) was started. However, the defect of the soft palate with necrotic tissues progressed, and the patient thus received extensive debridement of involved tissues and mucosa. The isolation of <I>Aspergillus flavus</I> from the soft palate and paranasal sinus was reported 7 days after the operation. A series of consolidation chemotherapy was safely performed by an administration of oral itraconazol and AMPH-B inhalation without a recurrence of aspergillosis. Not only is systemic treatment with antifungal agents required, but aggressive surgical debridement is also necessary for the cure of invasive <I>Aspergillus sinusitis</I>.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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