Cytomegalovirus Infection after Allogeneic Stem Cell Transplantation.
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概要
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We investigated the frequency of cytomegalovirus (CMV) infection and the strategy of the treatment by monitoring antigenemia weekly in 15 patients who received allogeneic stem cell transplantation from November 1996 to July 1998. Antigenemia became positive in 7 of 15 (46.7%) patients on 20-49 (median 29) days after transplantation, and clinical symptoms associated with CMV infection occurred in 5 of 7 (33.3%) patients. These 7 cases received transplantations from unrelated or mismatched donors, and antithymocyte globulin was used for 6 cases as preconditioning. Treatment was started with ganciclovir (GCV) immediately after antigenemia turned out positive, but the 2 patients whose antigenemia was slight (2/300, 000 WBCs) were observed without treatment. However, the number of their antigen positive cells increased to 15 and 68/300, 000 WBCs in a week. GCV seemed to be tolerant in 3 of 7 patients, who improved with foscarnet (FOS). An early initiation of treatment may be necessary if antigenemia becomes positive, and FOS is recommended if GCV seems to be ineffective.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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