Clinical Significance of Minimal Residual Disease in Childhood Leukemia.
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概要
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Recent progress in molecular biology contributes to the detection of MRD during hematological remission in leukemia. The clinical value of MRD monitoring is confused because its detectability is variable according to the disease, the treatment, and the methods. In t (1 ; 19) ALL, t (8 ; 21) AML, inv (16) ANLL, and CML, there is controversy regarding MRD in which the positive and negative MRD results during the long-term remission were described. It is necessary to quantitate the level of MRD in these diseases, however, in most cases of leukemia there appears to be good agreement between the detection of MRD and relapse. It is useful not only for the prediction of a relapse, but also for evaluation of the efficacy of the treatment and the choice of other treatments. Furthermore, it is hoped that protocol including the result of MRD will be made.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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