Two Children with Primary Mediastinal Large B Cell Lymphoma.
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概要
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We report two children with primary mediastinal large B cell lymphoma (PMLCL). Patient 1, a 10-year-old girl, presented with engorged veins on the chest and abdominal wall. MR image revealed a large mediastinal mass that invaded and occluded the superior vena cava. Patient 2, a 14-year-old boy, presented with swallowing discomfort and dry cough. Imaging study showed a huge mediastinal mass and pleural effusions. In both patients, the tumor cells showed mature B cell phenotype, and histopathology in patient 2 showed diffuse large-cell lymphoma with sclerosis. We treated them with an intensive short-term chemotherapy regimen "B-93 protocol." Both patients showed good response initially, but residual tumors were observed after the completion of chemotherapy. We confirmed complete remission by open biopsy in patient 1 and imaging study in patient 2. These two cases suggest that residual tumors of PMLCL are due to sclerosis and that they do not always show a resistance to treatment.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
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