Conversion of T-Cell Lymphoblastic Lymphoma to Acute Myeloid Leukemia Proved by Clonal Rearrangement of the T-Cell Receptor .DELTA. Gene.
スポンサーリンク
概要
- 論文の詳細を見る
A 10-year old boy was admitted to our hospital with generalized lymphoadenopathy. He had a mediastinal mass, but no organomegaly. Based on a right cervical lymph-node biopsy, he was diagnosed as having lymphoblastic-type non-Hodgkin's lymphoma (NHL). An immunological study of tumor cells showed only positive surface Ia and CD7 antigens. When the patient relapsed in the right inguinal lymph nodes, the tumor cells were positive for CD5, CD 10, and CD13. The blasts in the bone marrow 34 months after diagnosis showed additional positivity for CD1 lb, CD33, and CD34. A cytochemical study revealed positivity for peroxidase and Sudan-Black B staining. When we examined the gene rearrangement of the tumor cells at diagnosis, at relapse, and at myeloid conversion, they all showed the same T-cell receptor 6 gene rearrangement and germ line of the other genes. As a result, the monoclonality of tumor cells was confirmed. We therefore suspected that the NHL of this case originated from an immature prothymocyte (CD7 +) and thereafter developed into more differentiated lymphoid and/or myeloid precursor cells with the progression of disease and treatment.
- 特定非営利活動法人 日本小児血液・がん学会の論文
特定非営利活動法人 日本小児血液・がん学会 | 論文
- The Parent's Emotional Adaptation to the Children's Malignant Disease
- Side Effect of Cranial Radiation in Childhood Acute Leukemia
- Red Blood Cell Volume Distribution Width in Normal Children and in the Patients with Various Kinds of Hematological Disorders.
- Effective Conditioning of Donors for Granulocyte Transfusions with Recombinant Human Granulocyte Colony-Stimulating Factor.
- Two Infant Girls of CNS Leukemia with Chronic Subdural Hematoma